The study explores how glycosaminoglycans (GAGs) influence the angiogenic properties of type I collagen-based scaffolds. Researchers incorporated GAGs into collagen scaffolds and used the IKOSA CAM Assay and Network Formation Assay to evaluate vascular network...
The study evaluates the vascularization potential of two collagen-based scaffolds (2D and 3D structures) and a non-collagen scaffold implanted on the chick embryo chorioallantoic membrane (CAM). The researchers utilized classical stereomicroscopic imaging enhanced...
In this study, researchers investigated the potential of punicalagin as a supplementary treatment for osteosarcomas, the most prevalent primary malignant bone tumors affecting children, adolescents, and young adults. Despite current therapies like surgery and...
Welcome everybody to today’s interview. The topic today will be “Bridging Science and Ethics: The Evolution of CAM Models, Ethical Standards, and AI Advancements”. Elisa and I are very excited to be speaking with Sarah Barnett from the University of Liverpool today....
The growing public concern about the use of animals in research causes scholars to reevaluate and optimize existing experimental models. This has led to the rise of the 3Rs concept in animal testing. Thus, alternative in vivo and in vitro models fully replacing...
ZK002 is a novel protein isolated from the venom of the snake Deinagkistrodon acutus. It has been shown to have both anti-angiogenic and anti-inflammatory activities in both in vitro and in vivo studies. Mechanistically, ZK002 inhibits activation of VEGF signaling and...
Eggshell membrane (ESM) incorporated with silver nanoparticles (AgNPs) was developed as a promising wound-dressing material with enhanced antimicrobial, biological, and physical properties. Green-synthesized AgNPs displayed greater antimicrobial efficacy and stability...
We present to you a simple AI-driven method to analyze image data collected from the CAM assay model. Bear with us as we will explain to you how to effortlessly automate the entire image analysis process with the help of the IKOSA CAM Assay Application. Table of...
This paper presents a promising alternative in animal experimentation - the CAM assay using hen's eggs. The CAM provides a suitable environment for xenograft implantation, enabling the growth of human tumors. Evaluating therapeutic agents for efficacy and toxicity...
The chorioallantoic membrane (CAM) model is an alternative in vivo test system for studying cancer hallmarks, such as angiogenesis, tumor growth, immune escape, metastasis, and drug resistance. It is suitable for tumor cell lines and patient-derived xenografts (PDX),...
Malignant pleural mesothelioma is a cancer of the lung lining, normally caused by asbestos, that develops decades after exposure. Chemotherapy, and recently more targeted drugs, show some benefit although only a minority of patients respond and invariably the cancer...
Among in vivo angiogenesis assays, chick chorioallantoic membrane (CAM) assay has allowed meaningful progress in elucidating the mechanism of the vasoproliferative response to several pro- and antiangiogenic factors, thanks to its low costs, relatively easy...
Angiogenesis is a highly regulated process. It promotes tissue regeneration and contributes to tumor growth. Existing therapeutic concepts interfere with different steps of angiogenesis. The quantification of the vasculature is of crucial importance for research on...
(1) Background: Autosomal dominant polycystic kidney disease (ADPKD) is a frequent monogenic disorder that leads to progressive renal cyst growth and renal failure. Strategies to inhibit cyst growth in non-human cyst models have often failed in clinical trials. There...
(1) Background: angiogenesis plays an important role in the growth and metastasis of tumors. We established the CAM assay application, an image analysis software of the IKOSA platform by KML Vision, for the quantification of blood vessels with the in ovo...
The study evaluated the pro-angiogenic properties of a commercially available bovine bone-substitute material with hyaluronic acid (BSM+) in comparison to the same bone-substitute material without hyaluronic acid (BSM) in an in-vivo model. BSM+ and BSM were incubated...
Zinc oxide nanoparticles (ZnO NPs) are a promising material for tissue engineering applications. They have a wide range of biocompatibility, antibacterial properties, and can be modified to have different shapes, sizes, and functions. In a recent study, researchers...
As the chick chorioallantoic membrane (CAM) model raises in popularity in scientific literature, many researchers express interest in using automated bioimage analysis software tailored to the specifics of the CAM method. Our team...
In this article, we introduce five angiogenesis quantification software solutions that will help you harness the potential of AI-driven image analysis in vasculogenesis research. Find out how state-of-the-art computer vision technology will assist you in the study of...
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