This study explores the complexity of pancreatic ductal adenocarcinoma (PDAC) and its tumor microenvironment (TME), which plays a crucial role in treatment resistance. To better replicate this environment, the researchers developed triple co-culture spheroid models...
This article published in the Archives of Toxicology, addresses the integration of advanced imaging techniques into regulatory toxicology frameworks. It highlights the increasing use of imaging technologies in biomedical research and experimental toxicology to obtain...
The study highlights the growing interest in adipose tissue as an endocrine organ and its role in conditions like obesity, diabetes, cardiovascular disease, and cancer. Advanced technologies such as 3D cell cultures and Organ-on-a-Chip models are improving in vitro...
The study explores how glycosaminoglycans (GAGs) influence the angiogenic properties of type I collagen-based scaffolds. Researchers incorporated GAGs into collagen scaffolds and used the IKOSA CAM Assay and Network Formation Assay to evaluate vascular network...
The study evaluates the vascularization potential of two collagen-based scaffolds (2D and 3D structures) and a non-collagen scaffold implanted on the chick embryo chorioallantoic membrane (CAM). The researchers utilized classical stereomicroscopic imaging enhanced...
In this study, researchers investigated the potential of punicalagin as a supplementary treatment for osteosarcomas, the most prevalent primary malignant bone tumors affecting children, adolescents, and young adults. Despite current therapies like surgery and...
Traditional pathology utilizes stained blood smears viewed through microscopy, a technique still prevalent despite technological advancements. Typically, manual human assessment accompanies automated methods, maintaining simplicity but lacking comprehensive cell...
A new antibody has been developed to target Neuropilin-2 (NRP2), a receptor involved in processes like lymphangiogenesis, cancer, and inflammation. This antibody, unlike existing ones, is specifically designed for companion diagnostics. Tests using various methods...
ZK002 is a novel protein isolated from the venom of the snake Deinagkistrodon acutus. It has been shown to have both anti-angiogenic and anti-inflammatory activities in both in vitro and in vivo studies. Mechanistically, ZK002 inhibits activation of VEGF signaling and...
Eggshell membrane (ESM) incorporated with silver nanoparticles (AgNPs) was developed as a promising wound-dressing material with enhanced antimicrobial, biological, and physical properties. Green-synthesized AgNPs displayed greater antimicrobial efficacy and stability...
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