In this study, researchers investigated the potential of punicalagin as a supplementary treatment for osteosarcomas, the most prevalent primary malignant bone tumors affecting children, adolescents, and young adults. Despite current therapies like surgery and...
Traditional pathology utilizes stained blood smears viewed through microscopy, a technique still prevalent despite technological advancements. Typically, manual human assessment accompanies automated methods, maintaining simplicity but lacking comprehensive cell...
A new antibody has been developed to target Neuropilin-2 (NRP2), a receptor involved in processes like lymphangiogenesis, cancer, and inflammation. This antibody, unlike existing ones, is specifically designed for companion diagnostics. Tests using various methods...
ZK002 is a novel protein isolated from the venom of the snake Deinagkistrodon acutus. It has been shown to have both anti-angiogenic and anti-inflammatory activities in both in vitro and in vivo studies. Mechanistically, ZK002 inhibits activation of VEGF signaling and...
Eggshell membrane (ESM) incorporated with silver nanoparticles (AgNPs) was developed as a promising wound-dressing material with enhanced antimicrobial, biological, and physical properties. Green-synthesized AgNPs displayed greater antimicrobial efficacy and stability...
This paper addresses domain shifts in image analysis for diagnostics, causing compatibility issues with AI models for segmentation. Two approaches are presented: one using heuristic optimization to adapt input images through selected algorithms and parameter...
This paper presents a promising alternative in animal experimentation - the CAM assay using hen's eggs. The CAM provides a suitable environment for xenograft implantation, enabling the growth of human tumors. Evaluating therapeutic agents for efficacy and toxicity...
The chorioallantoic membrane (CAM) model is an alternative in vivo test system for studying cancer hallmarks, such as angiogenesis, tumor growth, immune escape, metastasis, and drug resistance. It is suitable for tumor cell lines and patient-derived xenografts (PDX),...
Prostate cancer is very frequent and is, in many countries, the third-leading cause of cancer-related death in men. While early diagnosis and treatment by surgical removal are often curative, metastasizing prostate cancer has a very bad prognosis. Based on the...
Malignant pleural mesothelioma is a cancer of the lung lining, normally caused by asbestos, that develops decades after exposure. Chemotherapy, and recently more targeted drugs, show some benefit although only a minority of patients respond and invariably the cancer...
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