Glycosaminoglycans Modulate the Angiogenic Ability of Type I Collagen-Based Scaffolds by Acting on Vascular Network Remodeling and Maturation

The study explores how glycosaminoglycans (GAGs) influence the angiogenic properties of type I collagen-based scaffolds. 

Researchers incorporated GAGs into collagen scaffolds and used the IKOSA CAM Assay and Network Formation Assay to evaluate vascular network formation, remodeling, and maturation. 

The results reveal that mixtures of glycosaminoglycans and type I collagen are the most effective scaffolds for promoting angiogenesis in tissue engineering, enabling the development of a fully functional vascular network. These findings emphasize the potential of GAG-functionalized collagen scaffolds in advancing tissue engineering applications.