Unlocking Angiogenesis Insights
Quantify Blood Vessels in Chick Chorioallantoic Membrane Assay using IKOSA’s deep learning technology
Streamline your CAM analysis with a suite of solid features
Automatically segment blood vessels
Accelerate your research by automating the measurement of total area, length, mean thickness, and the number of branching points of blood vessels.
Dive into the analysis results
Examine your results from every angle! Download a CSV or an Excel file including quantitative data on the detected vessels and their visualization. Information includes areas of detected vessels (blue overlay), vessel paths (green lines) and vessel branching points (red dots).
2D, time-series, Z-stacks & multichannel images
Perform analysis on single images or multidimensional datasets and obtain high-quality results.
Exclusively analyze a designated region
Specify one or multiple Regions of Interest (ROIs) to reduce the analysis time.
Exclusively analyze a designated region
Specify one or multiple Regions of Interest (ROIs) for performing the analysis.
Discover the potential of the IKOSA CAM Assay App for robust and cost-effective angiogenesis research.
Experts and key opinion leaders share their opinion
IKOSA CAM Assay: embraced by the scientific community
Delve into a comprehensive array of cases, interviews, and publications featuring prestigious institutions such as University Medical Center Mainz, University of Liverpool, University of Bari Aldo Moro, University of Regensburg, Medical University of Vienna, Utah Valley University, Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, and Medical University of Graz.
These resources spotlight the versatile applications of the CAM Assay in their groundbreaking research.
Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model—Possible Effects of Punicalagin
In this study, researchers investigated the potential of punicalagin as a supplementary treatment for osteosarcomas, the most prevalent primary...
A Conversation with Dr. Sarah Barnett About Ethical Standards and AI Image Analysis in CAM models
Welcome everybody to today’s interview. The topic today will be “Bridging Science and Ethics: The Evolution of CAM Models, Ethical Standards, and AI...
Inspiring Hope: How The 3Rs Framework and the CAM Assay Model Set New Standards in Animal Testing
The growing public concern about the use of animals in research causes scholars to reevaluate and optimize existing experimental models. This has...
Isolation and Characterization of ZK002, a Novel Dual Function Snake Venom Protein from Deinagkistrodon Acutus with Anti-Angiogenic and Anti-Inflammatory Properties
ZK002 is a novel protein isolated from the venom of the snake Deinagkistrodon acutus. It has been shown to have both anti-angiogenic and...
A Sustainable, Green-Processed, Ag-Nanoparticle-Incorporated Eggshell-Derived Biomaterial for Wound-Healing Applications
Eggshell membrane (ESM) incorporated with silver nanoparticles (AgNPs) was developed as a promising wound-dressing material with enhanced...
IKOSA Prisma in Action: Assessing Angiogenesis Hallmarks Within the CAM Assay Model
We present to you a simple AI-driven method to analyze image data collected from the CAM assay model. Bear with us as we will explain to you how to...
Toxicological Analysis by Assessment of Vascularization and Cell Viability Using the Chicken’s Chorioallantoic Membrane (CAM Assay)
This paper presents a promising alternative in animal experimentation - the CAM assay using hen's eggs. The CAM provides a suitable environment for...
The CAM Model—Q&A with Experts
The chorioallantoic membrane (CAM) model is an alternative in vivo test system for studying cancer hallmarks, such as angiogenesis, tumor growth,...
The Chick Embryo Xenograft Model for Malignant Pleural Mesothelioma: A Cost and Time Efficient 3Rs Model for Drug Target Evaluation
Malignant pleural mesothelioma is a cancer of the lung lining, normally caused by asbestos, that develops decades after exposure. Chemotherapy, and...
IKOSA® CAM Assay Application to Quantify Blood Vessels on Chick Chorioallantoic Membrane (CAM)
Among in vivo angiogenesis assays, chick chorioallantoic membrane (CAM) assay has allowed meaningful progress in elucidating the mechanism of the...
A Novel Artificial Intelligence-Based Approach for Quantitative Assessment of Angiogenesis in the Ex Ovo CAM Model
Angiogenesis is a highly regulated process. It promotes tissue regeneration and contributes to tumor growth. Existing therapeutic concepts interfere...
A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices
(1) Background: Autosomal dominant polycystic kidney disease (ADPKD) is a frequent monogenic disorder that leads to progressive renal cyst growth...
Deep Learning-Based Image Analysis for the Quantification of Tumor-Induced Angiogenesis in the 3D In Vivo Tumor Model—Establishment and Addition to Laser Speckle Contrast Imaging (LSCI)
(1) Background: angiogenesis plays an important role in the growth and metastasis of tumors. We established the CAM assay application, an image...
Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo
The study evaluated the pro-angiogenic properties of a commercially available bovine bone-substitute material with hyaluronic acid (BSM+) in...
Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials
Zinc oxide nanoparticles (ZnO NPs) are a promising material for tissue engineering applications. They have a wide range of biocompatibility,...
The Uses of CAM Assay Angiogenesis Analysis Software
As the chick chorioallantoic membrane (CAM) model raises in popularity in scientific literature, many researchers express interest in...
The Promise of AI in Angiogenesis Quantification
In this article, we introduce five angiogenesis quantification software solutions that will help you harness the potential of AI-driven image...
Watch our discussion about the CAM Assay with scientists from the Johannes Gutenberg-University Mainz
In this 12-minute video, meet Dr. Nadine Wiesmann and Dr Jonas Eckrich. We spoke with them about the diverse applications of the CAM Assay and its pivotal role in studying vascular processes.
Find your potential antiangiogenic cancer treatment strategy with reliable software.
Harness the power of deep learning within the IKOSA CAM Assay app, securing your position at the forefront of ethical considerations, cost-effectiveness, and streamlined processes.
Tips and tricks
Elevate your CAM image data analysis outcomes with our guidance.
CAM Assay: paving the path for 3R research
By offering the CAM Assay Application, we aim to contribute and expand the utilization of 3R-compliant research. Our goal is to eliminate the necessity for animal experiments altogether, while also reducing both the number of animals used and their distress during tests.