Investigations reporting positive effects of extracorporeal shockwave therapy (ESWT) on nerve regeneration are limited to the rat sciatic nerve model. The effects of ESWT on muscle-in-vein conduits (MVCs) have also not been investigated yet. This study aimed to...
Publications
Deep Learning-Based Image Analysis for the Quantification of Tumor-Induced Angiogenesis in the 3D In Vivo Tumor Model—Establishment and Addition to Laser Speckle Contrast Imaging (LSCI)
(1) Background: angiogenesis plays an important role in the growth and metastasis of tumors. We established the CAM assay application, an image analysis software of the IKOSA platform by KML Vision, for the quantification of blood vessels with the in ovo...
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro
Peripheral nerve injuries pose a major clinical concern world-wide, and functional recovery after segmental peripheral nerve injury is often unsatisfactory, even in cases of autografting. Although it is well established that angiogenesis plays a pivotal role during...
Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo
The study evaluated the pro-angiogenic properties of a commercially available bovine bone-substitute material with hyaluronic acid (BSM+) in comparison to the same bone-substitute material without hyaluronic acid (BSM) in an in-vivo model. BSM+ and BSM were incubated...
Validation of AI-based Information Systems for Sensitive Use Cases: Using an XAI Approach in Pharmaceutical Engineering
Artificial Intelligence (AI) is adopted in many businesses. However, adoption lacks behind for use cases with regulatory or compliance requirements, as validation and auditing of AI is still unresolved. AI's opaqueness (i.e., "black box") makes the validation...
Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials
Zinc oxide nanoparticles (ZnO NPs) are a promising material for tissue engineering applications. They have a wide range of biocompatibility, antibacterial properties, and can be modified to have different shapes, sizes, and functions. In a recent study, researchers...
Evolutionary Compromises in Fungal Fitness: Hydrophobins can Hinder the Adverse Dispersal of Conidiospores and Challenge Their Survival
Fungal evolutionary biology is impeded by the scarcity of fossils, irregular life cycles, immortality, and frequent asexual reproduction. Simple and diminutive bodies of fungi develop inside a substrate and have exceptional metabolic and ecological plasticity, which...
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