A study published in the International Journal of Implant Dentistry investigated the angiogenic potential of collagen membranes biofunctionalized with platelet-rich fibrin (PRF) and hyaluronic acid (HA) using an in ovo model. Different combinations of advanced and injectable PRF, as well as HA, were applied to collagen membranes commonly used in guided bone and tissue regeneration.
Membranes treated with PRF showed markedly enhanced angiogenesis compared with untreated controls, while HA improved vascularization to a lesser extent. Quantitative assessment was performed using the IKOSA® CAM Assay, enabling objective measurement of vessel area, total vessel length, branching points, and vessel thickness.
These findings suggest that PRF and HA biofunctionalization may improve vascular support in tissue and bone regeneration, although further clinical studies are required to confirm their effectiveness in human applications.
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